Alzheimer’s disease for the first time could cure! There will soon be starogo of insanity! – Ukr.Media

2018-04-04 14:15

Alzheimer’s disease for the first time could cure! There will soon be starogo of insanity!
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Lock the mutated gene can stop the formation of amyloid plaques in the brain. In this way, scientists at the University of Washington managed to eliminate the symptoms of Alzheimer’s disease in mice, reports Rus.Media.

Approximately 20 years before the first symptoms of Alzheimer’s disease (e.g. memory issues) in the brain of people are already starting to accumulate beta-amyloid proteins.

According to researchers, these protein accumulations inhibit the transmission of neural signals from one brain to another. This leads to the fact that over time a person has memory problems and disturbed cognitive processes.

Us scientists have developed antibodies that can neutralize proteins responsible for the formation of dangerous brain plaques.

In previous studies, complete extraction has led to serious violations in the brain development of mice.

The fact is that beta-amyloid proteins called APOE takes part in several fundamental processes of development.

The protein APOE is one of the most important molecules in the cells of the brain and other parts of the body, it is associated with metabolism and circulation of cholesterol and fatty acids in the body.

The presence of certain gene variation APOE indicates that the person is predisposed to Alzheimer’s disease in the future she may develop dementia.

For example, the mutation APOE4 carriers which are 10% of the population of the planet increases the likelihood of developing Alzheimer’s disease 3 times. A person with two copies of the mutation suggests that the onset of Alzheimer’s disease is almost inevitable.

A new alternative approach will significantly mitigate the side effects, and eliminate the formation of protein clusters even long before a person will have any symptoms.

Scientists have created an experimental method for which they used antibodies to find and destroy the insidious proteins in the brains of mice.

Antibodies on the image above marked in red, the amyloid proteins that contribute to the development of Alzheimer’s, purple.

Experts have divided the rodents into two groups: the first received injections of drugs from the first day of my life (the brain of these mice did not contain large clusters of dangerous proteins), the second group of mice at the beginning of the experiment already had symptoms of Alzheimer’s disease.

More good injection brought the first group of mice, which has not yet touched on the disease. The second group was not so lucky – even after blocking APOE, they continued to suffer starchem dementia.

On the other hand, drugs were able to slow the progression of the disease and in fact, in another case.

Thus, the study showed that blocking APOE really helps to prevent the development of Alzheimer’s disease, but only if this procedure can start before the appearance of its visible traces.

Hopefully, scientists will not stop here and soon mankind will receive the effective drugs that can prevent the onset of disease.

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