A average dose prolonged, ibuprofen, affects the production of testosterone

Health 9 January, 2018


Published the 09.01.2018 at 21h21


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Making regular and continuous ibuprofen, which is common in medication, family and frequently misuse among young men in high-level athletes, disrupts the normal functioning of the testis and leads to a hormonal imbalance and disturbances in the formation of sperm, usually encountered in elderly men, and is called hypogonadism offset “. This is what emerges from a study published in a scientific journal, the Proceedings of the National Academy of Sciences.

A painkiller common

Ibuprofen is a nonsteroidal anti-inflammatory drugs, ” NSAIDS “, on sale free. There is almost no longer used as a NSAID in France. The bulk of consumption is in the indications of pain, that is to say between 200 and 1200 milligrams per day. It is so widely consumed, in the adult as in the child, in the short-term treatment of fever and influenza states, or pains such as headaches or teeth, aches, and very often in painful menstruation. It is contraindicated in a child in cases of chicken pox and pregnant women beyond six months.

Abuse in sport

As it is easy to access and effective, it is also unfortunately far too used and in particular among high-level athletes, self-medication, and under the pressure of their entourage. It is almost a reflex in the bad sports halls to prevent the aches of an effort than usual or too much supported by the cures of ibuprofen. The less scrupulous adding of the corticosteroids which has seen the devastation in platoons cyclists, including among small fans. And the risk benefit here to be more important than the property.

A study worrying for the man

A study conducted at the University of Copenhagen and co-ordinated by Inserm alert on the harmful effects and not hitherto known on the functioning of testicles.
The study was conducted on 31 male volunteers sports from 18 to 35 years old who were firing at random to take either ibuprofen, 1200 mg for 6 weeks, or a placebo. The study was then analyzed fragments of testes were cultured.

A global perturbation of the testis

The findings of the clinical trial show that, when the men were exposed to 1200 mg of ibuprofen per day for 6 weeks, the levels of the pituitary hormone, a hormone that plays a key role in the control of the production of testosterone, were strongly elevated in the blood, which has caused disruption in the production of the testosterone.
Moreover, ibuprofen also acts on other hormones produced in the testis and disrupt fully the manufacturing cycle of the sperm.

A state of “hypogonadism offset”

In total, this study demonstrates that the prolonged intake of doses of pain relief, that is to say the average doses of ibuprofen (1200 mg/day for 6 weeks, or 3 tablets on 400 mg), exerts endocrine-disrupting effects severe young men leading to a state of ” hypogonadism offset “, a condition that is usually encountered in approximately 10% of older men in which testosterone production decreases. This situation is generally associated with increased risks for fertility, such as for general health.
And for Bernard Jégou, director of research at Inserm and coordinator of the study ” there are men who take an on-going basis to ibuprofen (…). If this state of hypogonadism offset settles, the risk for them is to increase the risks already associated with this medicine, but also to alter their physical condition (muscles and bones), and to hypothecate their reproductive health and even psychological “.

A molecule under surveillance

Ibuprofen is already contra-indicated beyond the 6th month of pregnancy because it is responsible for fetal malformations. But, a recent study has also shown that ibuprofen taken during pregnancy could also disrupt the formation of the testes of the fetal male after the first few months of development in the uterus.

Ibuprofen is not a drug harmless. It is necessary to take reasonable and if the plug is prolonged, it is best to consult his doctor. And the ban in the pregnant woman and sportsman of the absolute.