Alzheimer’s disease : opportunities for a large study prevention

luckybusiness/epictura

Published the 29.12.2017 at 23h35

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disease alzheimerInflammationprogressionprévention

There is still no treatment for Alzheimer’s disease. Each year, in France, 225 000 new cases are still diagnosed.
Researchers in germany have conducted a study, published in the journal Nature, which is a further step towards the understanding of the development of the disease.
According to the results of this study, the immune system of the brain can cause inflammation, which causes the symptoms of this disease, ” memory “.

Deposit of “plaques” and the appearance of symptoms

The research on Alzheimer’s disease has already been observed that it results in an abnormal production of small proteins related to ageing in the brain, beta-amyloid (” Abeta “).
These proteins form so-called “amyloid beta plaques” in the brain, and cause a malfunction in some of its neural circuitry. The cognitive functions of the individual (memory, language, reasoning, attention) are affected first.
Alzheimer’s disease is a neurodegenerative disease. Eventually, it led to the death of neurons and dementia.

The inflammation causes the symptoms, not the reverse

When the deposit of amyloid beta plaques progresses in the brain, this triggers an immune response of type ” innate “. Production of molecules, release of signaling proteins by the cells. In short, it is activated. And according to the researchers of the study, this inflammatory reaction, the non-specific is related to the onset of symptoms.
At the beginning of the disease, the first symptoms may be from forgetting to repeat, ask, everyday objects in inappropriate places (the keys of the house in the micro-wave), do not use words correctly, to have the judgment altered (say it is cold when it is hot, for example).

What hope is there for the prevention of the disease

According to the German researchers, the therapeutic response in Alzheimer’s disease may find themselves in the inflammatory immune response in the brain. Targeting the innate immune system of the brain could allow you to act on the symptoms. To prevent trigger-by-example.
It is for this reason that it is important to study the patients at a very early stage of the disease. It is for this reason that it is necessary to form groups of people who are still young to follow them in time and act as soon as the early mechanisms of the disease are in motion and not just act when these mechanisms have already given of the lesions that are responsible for the first clinical signs.

Join the cohort of the Pitié-Salpêtrière hospital

We may have effective drugs, but because of the have used it early enough, we don’t know. You may be the first abnormalities that will lead to the installation of the lesions of Alzheimer’s, but without the searching, so you don’t know.
If you are over the age of 60 years, if you complain of memory problems, join the cohort of the Institute for memory and Alzheimer disease (IM2A) of the hospital of the Pitié-Salpêtrière hospital, in Paris.
You will be followed closely for several years : you will have blood tests and MRI of the edge and, if you are at risk, of drugs in prevention. It is a real a therapeutic project is innovative.

To volunteer : Call 06 60 38 58 62