WHO : A promising treatment against malaria
Published the 29.01.2018 at 08h05
A new combination of drugs seems to be very effective against malaria (malaria) according to professor Peter Kremsner, Institute of Tropical Medicine in Tübingen. In the study, the researchers tested the effectiveness and tolerance of a combination of 2 medicines fosmidomycin and piperaquine.
This association was maintained for three days in patients aged one to thirty years with Plasmodium falciparum malaria. In the 83 cases evaluable, there is a cure rate of 100%. The patients have tolerated the treatment resulted in a rapid reduction of clinical symptoms.
In the nails, the WHO
“This study represents an important step in clinical research on the fosmidomycin,” says lead author Peter Kremsner. The substance was originally extracted from Streptomyces lavendulae and can now be produced synthetically. It blocks a metabolic pathway for the production of isoprenoids in plasmodium.
Patients tolerate the drug and have virtually no side effects. In addition, the new combination perfectly meets the WHO guidelines which demand to be effective treatments, but without artemisine. The mechanisms of action of these 2 drugs acting independently of one another against the various target structures of the parasite, in the blood circulation.
This meets the WHO requirements for quick and effective treatment of the acute phase of the infection, and to protection against relapse due to the persistence of the parasite in the body.